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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">CCL5</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_CCL5" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
<tbody><tr>
<th colspan="3" style="background:#90EE90; color:#202122;">CCL5
</th></tr>
<tr style="text-align:center;">
<td colspan="3"><span typeof="mw:File"></span>
</td></tr>
<tr>
<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">nach <a href="Protein_Data_Bank" title="Protein Data Bank">PDB</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1EQT">1EQT</a>
</td></tr>
<tr>
<td>Andere Namen
</td>
<td colspan="2">
<ul><li>RANTES</li>
<li>Chemokine (C-C Motif) Ligand 5</li>
<li>SIS-Delta</li>
<li>D17S136E</li>
<li>TCP228</li>
<li>Eosinophil Chemotactic Cytokine</li>
<li>T-Cell Specific Protein P288</li>
<li>Beta-Chemokine</li>
<li>EoCP</li>
<li>Regulated Upon Activation, Normally T-Expressed, And Presumably Secreted</li>
<li>Small Inducible Cytokine Subfamily A (Cys-Cys), Member 5;</li>
<li>C-C Motif Chemokine 5</li></ul>
</td></tr>
<tr>
<td colspan="3" class="hintergrundfarbe1" style="font-size:smaller;">
<p>Vorhandene Strukturdaten: <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1B3A">1B3A</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1EQT">1EQT</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1HRJ">1HRJ</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1RTN">1RTN</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1RTO">1RTO</a></span>, <span class=""><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1U4L">1U4L</a></span>
</p>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;;">Eigenschaften des menschlichen Proteins
</th></tr>
<tr>
<td><a href="Molare_Masse" title="Molare Masse">Masse</a>/Länge <a href="Prim%C3%A4rstruktur" title="Primärstruktur">Primärstruktur</a>
</td>
<td colspan="2" style="text-align:center;">91 Aminosäuren, 9990 Da
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
</th></tr>
<tr>
<td>Externe IDs
</td>
<td colspan="2" class="">
<ul><li><a href="GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="http://www.genecards.org/cgi-bin/carddisp.pl?gene=CCL5">CCL5</a></li>
<li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/187011">187011</a></li>
<li><a href="UniProt" title="UniProt">UniProt</a> <a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P13501">P13501</a></li></ul>
</td></tr>
<tr>
<th colspan="3" style="background:#90EE90; color:#202122;">Vorkommen
</th></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">Homologie-Familie
</td>
<td colspan="2" style="text-align:center;"><a rel="nofollow" class="external text" href="http://hogenom.univ-lyon1.fr/query_sequence?seq=P13501">Hovergen</a>
</td></tr>
<tr>
<td colspan="3" style="background:#90EE90; color:#202122; text-align:center;"><a href="Homologie_(Genetik)#Homologie_zwischen_verdoppelten_oder_fremden_Genen" title="Homologie (Genetik)">Orthologe</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;">
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Mensch
</td>
<td style="background:#C3FDB8; color:#202122; text-align:center;">Hausmaus
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="Entrez_Gene" title="Entrez Gene">Entrez</a>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=6352&rn=1">6352</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=20304&rn=1">20304</a></span>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="UniProt" title="UniProt">UniProt</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P13501">P13501</a>
</td>
<td><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprotkb/P30882">P30882</a>
</td></tr>
<tr>
<td style="background:#C3FDB8; color:#202122;"><a href="PubMed" title="PubMed">PubMed</a>-Suche
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=6352">6352</a></span>
</td>
<td><span class=""><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=20304">20304</a></span>
<p><span class="editoronly" style="display:none;"></span>
</p>
</td></tr></tbody></table><p><span class="editoronly" style="display:none;"></span>
</p><p><b>CCL5</b> (<span style="font-style:normal;font-weight:normal"><a href="Englische_Sprache" title="Englische Sprache">englisch</a></span> <span lang="en-Latn" style="font-style:italic">CC-chemokine ligand 5</span>) ist ein <a href="Zytokin" title="Zytokin">Zytokin</a> aus der Familie der CC-<a href="Chemokin" title="Chemokin">Chemokine</a>.
</p>
<div class="mw-heading mw-heading2"><h2 id="Eigenschaften">Eigenschaften</h2></div>
<p>CCL5 ist an <a href="Entz%C3%BCndung" title="Entzündung">Entzündungsprozessen</a> beteiligt. CCL5 wird unter anderem von <a href="Zytotoxische_T-Zelle" title="Zytotoxische T-Zelle">zytotoxischen T-Zellen</a> gebildet und bindet <a href="T-Zelle" class="mw-redirect" title="T-Zelle">T-Zellen</a>, <a href="Monozyt" title="Monozyt">Monozyten</a> und <a href="Eosinophile" class="mw-redirect" title="Eosinophile">Eosinophile</a> durch Bindung der <a href="Rezeptor_(Biochemie)" title="Rezeptor (Biochemie)">Rezeptoren</a> <a href="CCR3" title="CCR3">CCR3</a>,<sup id="cite_ref-pmid8642344_1-0" class="reference"><a href="#cite_note-pmid8642344-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11449371_2-0" class="reference"><a href="#cite_note-pmid11449371-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> <a href="CCR5" title="CCR5">CCR5</a><sup id="cite_ref-pmid11449371_2-1" class="reference"><a href="#cite_note-pmid11449371-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid14637022_3-0" class="reference"><a href="#cite_note-pmid14637022-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11116158_4-0" class="reference"><a href="#cite_note-pmid11116158-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> und <a href="CCR1" title="CCR1">CCR1</a>.<sup id="cite_ref-pmid11449371_2-2" class="reference"><a href="#cite_note-pmid11449371-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11116158_4-1" class="reference"><a href="#cite_note-pmid11116158-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> CCL5 aktiviert den <a href="G-Protein-gekoppelter_Rezeptor" class="mw-redirect" title="G-Protein-gekoppelter Rezeptor">GPCR</a> GPR75.<sup id="cite_ref-pmid17001303_5-0" class="reference"><a href="#cite_note-pmid17001303-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p>CCL5 ist an der Abwehr von Infektionen mit <a href="HIV" title="HIV">HIV</a>-1 beteiligt,<sup id="cite_ref-pmid8525373_6-0" class="reference"><a href="#cite_note-pmid8525373-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> da es die Bindung von HIV an seinen Korezeptor CCR5 <a href="Kompetitive_Hemmung" title="Kompetitive Hemmung">kompetitiv</a> hemmt.
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-pmid8642344-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid8642344_1-0">↑</a></span> <span class="reference-text">Daugherty BL, Siciliano SJ, DeMartino JA, Malkowitz L, Sirotina A, Springer MS: <cite style="font-style:italic">Cloning, expression, and characterization of the human eosinophil eotaxin receptor</cite>. In: <cite style="font-style:italic">J. Exp. Med.</cite> 183. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5</span>, Mai 1996, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>2349–54</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1084/jem.183.5.2349">10.1084/jem.183.5.2349</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/8642344?dopt=Abstract">PMID 8642344</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192548/">PMC 2192548</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL5&rft.atitle=Cloning%2C+expression%2C+and+characterization+of+the+human+eosinophil+eotaxin+receptor&rft.au=Daugherty+BL%2C+Siciliano+SJ%2C+DeMartino+JA%2C+...&rft.date=1996-05&rft.doi=10.1084%2Fjem.183.5.2349&rft.genre=journal&rft.issue=5&rft.jtitle=J.+Exp.+Med.&rft.pages=2349-54&rft.pmc=2192548&rft.pmid=8642344&rft.volume=183.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid11449371-2"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-pmid11449371_2-0">a</a></sup> <sup><a href="#cite_ref-pmid11449371_2-1">b</a></sup> <sup><a href="#cite_ref-pmid11449371_2-2">c</a></sup></span> <span class="reference-text">Struyf S, Menten P, Lenaerts JP, Put W, D’Haese A, De Clercq E, Schols D, Proost P, Van Damme J: <cite style="font-style:italic">Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils</cite>. In: <cite style="font-style:italic">Eur. J. Immunol.</cite> 31. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>7</span>, Juli 2001, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>2170–8</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/1521-4141%28200107%2931%3A7%3C2170%3A%3AAID-IMMU2170%3E3.0.CO%3B2-D">10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11449371?dopt=Abstract">PMID 11449371</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL5&rft.atitle=Diverging+binding+capacities+of+natural+LD78beta+isoforms+of+macrophage+inflammatory+protein-1alpha+to+the+CC+chemokine+receptors+1%2C+3+and+5+affect+their+anti-HIV-1+activity+and+chemotactic+potencies+for+neutrophils+and+eosinophils&rft.au=Struyf+S%2C+Menten+P%2C+Lenaerts+JP%2C+...&rft.date=2001-07&rft.doi=10.1002%2F1521-4141%28200107%2931%3A7%3C2170%3A%3AAID-IMMU2170%3E3.0.CO%3B2-D&rft.genre=journal&rft.issue=7&rft.jtitle=Eur.+J.+Immunol.&rft.pages=2170-8&rft.pmid=11449371&rft.volume=31.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid14637022-3"><span class="mw-cite-backlink"><a href="#cite_ref-pmid14637022_3-0">↑</a></span> <span class="reference-text">Slimani H, Charnaux N, Mbemba E, Saffar L, Vassy R, Vita C, Gattegno L: <cite style="font-style:italic">Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages</cite>. In: <cite style="font-style:italic">Biochim. Biophys. Acta</cite>. 1617. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1–2</span>, Oktober 2003, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>80–8</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/j.bbamem.2003.09.006">10.1016/j.bbamem.2003.09.006</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/14637022?dopt=Abstract">PMID 14637022</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL5&rft.atitle=Interaction+of+RANTES+with+syndecan-1+and+syndecan-4+expressed+by+human+primary+macrophages&rft.au=Slimani+H%2C+Charnaux+N%2C+Mbemba+E%2C+...&rft.date=2003-10&rft.doi=10.1016%2Fj.bbamem.2003.09.006&rft.genre=journal&rft.issue=1-2&rft.jtitle=Biochim.+Biophys.+Acta&rft.pages=80-8&rft.pmid=14637022&rft.volume=1617.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid11116158-4"><span class="mw-cite-backlink">↑ <sup><a href="#cite_ref-pmid11116158_4-0">a</a></sup> <sup><a href="#cite_ref-pmid11116158_4-1">b</a></sup></span> <span class="reference-text">Proudfoot AE, Fritchley S, Borlat F, Shaw JP, Vilbois F, Zwahlen C, <a href="Alexandra_Trkola" title="Alexandra Trkola">Trkola A</a>, Marchant D, Clapham PR, Wells TN: <cite style="font-style:italic">The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity</cite>. In: <cite style="font-style:italic">J. Biol. Chem.</cite> 276. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>14</span>, April 2001, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>10620–6</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1074/jbc.M010867200">10.1074/jbc.M010867200</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/11116158?dopt=Abstract">PMID 11116158</a>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL5&rft.atitle=The+BBXB+motif+of+RANTES+is+the+principal+site+for+heparin+binding+and+controls+receptor+selectivity&rft.au=Proudfoot+AE%2C+Fritchley+S%2C+Borlat+F%2C+...&rft.date=2001-04&rft.doi=10.1074%2Fjbc.M010867200&rft.genre=journal&rft.issue=14&rft.jtitle=J.+Biol.+Chem.&rft.pages=10620-6&rft.pmid=11116158&rft.volume=276.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid17001303-5"><span class="mw-cite-backlink"><a href="#cite_ref-pmid17001303_5-0">↑</a></span> <span class="reference-text">Ignatov A, Robert J, Gregory-Evans C, Schaller HC: <cite style="font-style:italic">RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75</cite>. In: <cite style="font-style:italic">Br. J. Pharmacol.</cite> 149. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5</span>, November 2006, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>490–7</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/sj.bjp.0706909">10.1038/sj.bjp.0706909</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/17001303?dopt=Abstract">PMID 17001303</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014681/">PMC 2014681</a> (freier Volltext).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL5&rft.atitle=RANTES+stimulates+Ca2%2B+mobilization+and+inositol+trisphosphate+%28IP3%29+formation+in+cells+transfected+with+G+protein-coupled+receptor+75&rft.au=Ignatov+A%2C+Robert+J%2C+Gregory-Evans+C%2C+...&rft.date=2006-11&rft.doi=10.1038%2Fsj.bjp.0706909&rft.genre=journal&rft.issue=5&rft.jtitle=Br.+J.+Pharmacol.&rft.pages=490-7&rft.pmc=2014681&rft.pmid=17001303&rft.volume=149.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-pmid8525373-6"><span class="mw-cite-backlink"><a href="#cite_ref-pmid8525373_6-0">↑</a></span> <span class="reference-text">Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P: <cite style="font-style:italic">Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells</cite>. In: <cite style="font-style:italic">Science</cite>. 270. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5243</span>, Dezember 1995, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1811–5</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1126/science.270.5243.1811">10.1126/science.270.5243.1811</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/8525373?dopt=Abstract">PMID 8525373</a> (<a rel="nofollow" class="external text" href="https://science.sciencemag.org/content/270/5243/1811">sciencemag.org</a>).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:CCL5&rft.atitle=Identification+of+RANTES%2C+MIP-1+alpha%2C+and+MIP-1+beta+as+the+major+HIV-suppressive+factors+produced+by+CD8%2B+T+cells&rft.au=Cocchi+F%2C+DeVico+AL%2C+Garzino-Demo+A%2C+...&rft.date=1995-12&rft.doi=10.1126%2Fscience.270.5243.1811&rft.genre=journal&rft.issue=5243&rft.jtitle=Science&rft.pages=1811-5&rft.pmid=8525373&rft.volume=270.+Jahrgang" style="display:none"> </span></span>
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